Study of gall bladder disease with incidence of gall bladder malignancy
Abstract
Background: To identify and evaluate the predisposing factor in gall bladder disease prospectively and to study the incidence of gall bladder malignancy in gall bladder disease.
Methods: The present study included 240 patients who were distributed in three groups. About 198 patients of cholelithiasis, 27 patients of carcinoma gall bladder and 15 other patients of gall bladder disease were included. Findings of the patients were tabulated to reach the possible association of the factors concerned with a particular gall bladder disease.
Results: The highest incidence of carcinoma gall bladder was in 7th decade oflife in females and 6th decade in males and the highest incidence of cholelithiasis in 6th decade for males as well as females. Carcinoma gall bladder in females was 2.375 times more than males while this ratio in gallstones was 1: 2.54 in favor of females.
Conclusion: Gallstone associated symptoms are non-specific and accurate diagnosis cannot be reliedonclinical assessment alone.Careful clinical evaluation can guide patient selection for diagnostic imaging andappropriate management of those found to harbor stones.
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References
2. MA, Volk H. primary carcinoma of the ball bladder: A Ten year review. Am J. Surg 1970:120-800.[pubmed]
3. Klein JB, Finck FM. Primary carcinoma of the gallbladder. Review of 28 cases. Arch Surg. 1972 Jun; 104(6):769-72.[pubmed]
4. Ohlsson EG, Aronsen KF. Carcinoma of the gallbladder.A study of 181 cases. Acta Chir Scand. 1974;140(6):475-80.[pubmed]
5. THORBJARNARSON B. Carcinoma of the gallbladder and acute cholecystitis. Ann Surg. 1960 Feb;151:241-4.[pubmed]
6. Layde PM, Vessey MP, Yeates D. Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics. J Epidemiol Community Health. 1982 Dec;36(4):274-8.[pubmed]
7. Shaffer EA. Gallstone disease: Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20(6):981-96.DOI:10.1016/j.bpg.2006.05.004
8. Friedman GD, Kannel WB, Dawber TR. The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966 Mar;19(3):273-92.[pubmed]
9. Stinton LM1, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver. 2012 Apr;6(2):172-87. doi: 10.5009/gnl.2012.6.2.172. Epub 2012 Apr 17.[pubmed]
10. Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 1992 Sep 15;70(6):1493-7.[pubmed]
11. Axelrod L, Munster AM, O'Brien TF. Typhoid cholecystitis and gallbladder carcinoma after interval of 67 years. JAMA. 1971 Jul 5;217(1):83.[pubmed]
12. Balaroutsos C, Bastounis E, Karamanakos P, et al. Primary carcinoma of the gallbladder: analysis of 22 cases. Am Surg. 1974 Oct;40(10):605-8.[pubmed]
13. Chao TC, Greager JA primary carcinoma of the gall bladder J drug oncol 1991;46:2015-221.
14. Sampliner RE, Bennett PH, Comess LJ, et al. Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970 Dec 17;283(25):1358-64. DOI:10.1056/NEJM197012172832502.[pubmed]
15. Jørgensen T. Abdominal symptoms and gallstone disease: an epidemiological investigation. Hepatology. 1989 Jun;9(6):856-60.[pubmed]
16. Portincasa P, Moschetta A, Petruzzelli M, et al. Gallstone disease: Symptoms and diagnosis of gallbladder stones. Best Pract Res Clin Gastroenterol. 2006;20(6):1017-29.[pubmed]
17. Diehl AK1, Sugarek NJ, Todd KH. Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis. Am J Med. 1990 Jul;89(1):29-33.[pubmed]
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