Familial Meckel's diverticulum - still a mystery. A retrospective caseseries in a tertiary care centre in South India
Keywords:
Meckel's Diverticulum, Familial, Congenital, Complications
Abstract
Meckel's diverticulum is the most frequent congenital malformation of the gastrointestinal tract.Though a congenital abnormality, it rarely requires surgery. Although, there is no definite probabilityof familial predisposition, a few cases occurring within the same family have been reported.Retrospective case series of 2 siblings with incidentally detected Meckel's diverticulum withappendicitis. Conclusion: There exists the probability of familial predisposition of Meckel’sdiverticulum. Careful consideration should be made in siblings or relatives of a previously diagnosedMeckel’s diverticulum. Early exploration should be done to prevent morbidity and mortalityassociated with late complications.
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References
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6. Lewenstein HJ, Levenson SS. Familial occurrence of Meckel’s diverticulum. N Engl J Med. 1963;268:311-2. doi: 10.1056/NEJM196302072680611, PMID 13930306.
7. Stone PA, Hofeldt MJ, Lohan JA, Kessel JW, Flaherty SK. A rare case of massive gastrointestinal hemorrhage caused by Meckel’s diverticulum in a 53-year-old man. W V Med J. 2005;101(2):64-6. PMID 16042089, Google Scholar.
8. Yorganci K, Ozdemir A, Hamaloglu E, Sokmener C. Perforation of acute calculous Meckel’s diverticulitis: a rare cause of acute abdomen in elderly. Acta Chir Belg. 2000;100(5):226-7. PMID 11143326, Google Scholar.
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13. Kusumoto H, Yoshida M, Takahashi I, Anai H, Maehara Y, Am Sugimachi K. Complications and diagnosis of Meckel’s diverticulum in 776 patients. Am J Surg. 1992 Oct;164(4):382-3. doi: 10.1016/s0002-9610(05)80909-2, PMID 1415948.
14. Heinicke JM, Tedaldi R, Muller C. An unusual manifestation of Meckel’s diverticulum: bleeding and perforation—a case report. Swiss Surg. 1997;3(3):97-9. PMID 9200969, Google Scholar.
15. Wong JH, Suhaili DN, Kok KY. Fish bone perforation of Meckel’s diverticulum: a rare event? Asian J Surg. 2005;28(4):295-6. doi: 10.1016/s1015-9584(09)60364-x, PMID 16234083, Google Scholar.
16. Tan YM, Zheng ZX. Recurrent torsion of a giant Meckel’s diverticulum. Dig Dis Sci. 2005;50(7):1285-7. doi: 10.1007/s10620-005-2774-7, PMID 16047474, Google Scholar.
17. Puligandla PS, Becker L, Driman D, Prokopiw I, Taves D, Davies ET. Inverted Meckel’s diverticulum presenting as chronic anemia: case report and literature review. Can J Surg. 2001;44(6):458-9. (PMC Free article). PMID 11764882, Google Scholar.
18. Soltero MJ, Bill AH. The natural history of Meckel’s diverticulum and its relation to incidental removal. A study of 202 cases of diseased Meckel’s diverticulum found in King County, Washington, over a fifteen year period. Am J Surg. 1976;132(2):168-73. doi: 10.1016/0002-9610(76)90043-x, PMID 952346, Google Scholar.
19. Kusumoto H, Yoshida M, Takahashi I, Anai H, Maehara Y, Am Sugimachi K. Complications and diagnosis of Meckel’s diverticulum in 776 patients. Am J Surg. 1992 Oct;164(4):382-3. doi: 10.1016/s0002-9610(05)80909-2, PMID 1415948.
20. Ymaguchi M, Takeuchi S, Awazu S. Meckel’s diverticulum. Investigation of 600 patients in Japanese literature. Am J Surg. 1978;136(2):247-9. doi: 10.1016/0002-9610(78)90238-6, PMID 308325.
21. Lorusso R, Forte A, Urbano V, Soda G, D’Urso A, Bosco MR, Mancini P, Bezzi M. Small bowel stromal tumors in a ”Meckelian” location. About a clinical observation. Ann Ital Chir. 2003;74(6):707-11. PMID 15206814, Google Scholar.
22. Sutter PM, Canepa MG, Kuhrmeier F, Marx A, Martinoli S. Carcinoid tumor in Meckel’s diverticulum: case presentation and review of the literature. Schweiz Med Wochenschr Suppl. 1997;89:20S-4S. PMID 9289835, Google Scholar.
23. Stone PA, Hofeldt MJ, Campbell JE, Vedula G, DeLuca JA, Flaherty SK. Meckel diverticulum: ten-year experience in adults. South Med J. 2004;97(11):1038-41. doi: 10.1097/01.SMJ.0000125222.90696.03, PMID 15586591, Google Scholar.
24. Nayak B, Dash RR, Mallik BN. Perforated Meckel’s diverticulum as a result of gastrointestinal stromal tumor presenting as acute abdomen: A rare case report. Onc Gas Hep Rep. 2015;4(1):26. doi: 10.4103/2348-3113.139636.
25. Parente F, Anderloni A, Zerbi P, Lazzaroni M, Sampietro G, Danelli P, Bianchi Porro G. Intermittent small-bowel obstruction caused by gastric adenocarcinoma in a Meckel’s diverticulum. Gastrointest Endosc. 2005;61(1):180-3. doi: 10.1016/s0016-5107(04)02450-2, PMID 15672086.
26. Hager M, Maier H, Eberwein M, Klingler P, Kolbitsch C, Tiefenthaler W, Mikuz G, Moser PL. Perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor: a case report. J Gastrointest Surg. 2005;9(6):809-11. doi: 10.1016/j.gassur.2004.12.005, PMID 16189886.
27. Payne-James JJ, Law NW, Watkins RM. Carcinoid tumour arising in a Meckel’s diverticulum. Postgrad Med J. 1985;61(721):1009-11. doi: 10.1136/pgmj.61.721.1009, PMID 4070108.
28. Dimitriou I, Evaggelou N, Tavaki E, et al. PMC free articlePerforation of Meckel’s diverticulum by a fish bone presenting as acute appendicitis: a case report. J Med Case Rep. 2013;7:231. doi: 10.1186/1752-1947-7-231, PMID 24088307 [CrossRef]. Google Scholar.
29. Chan KW. Perforation of Meckel’s diverticulum caused by a chicken bone: a case report. J Med Case Rep. 2009;3:48. doi: 10.1186/1752-1947-3-48. (PMC Free article). PMID 19192283 [CrossRef], Google Scholar.
30. Ding Y, Zhou Y, Ji Z, Zhang J, Wang Q. Laparoscopic management of perforated Meckel’s diverticulum in adults. Int J Med Sci. 2012;9(3):243-7. doi: 10.7150/ijms.4170. (PMC Free article). PMID 22577339 [CrossRef], Google Scholar.
31. Shalaby RY, Soliman SM, Fawy M, Samaha A. Laparoscopic management of Meckel’s diverticulum in children. J PediatrSurg. J Pediatr Surg. 2005;40(3):562-7. doi: 10.1016/j.jpedsurg.2004.11.032, PMID 15793736, Google Scholar.
32. Chan KW, Lee KH, Mou JW, Cheung ST, Tam YH. Laparoscopic management of complicated Meckel’s diverticulum in children: a 10-year review. Surg Endosc. 2008 Jun;22(6):1509-12. doi: 10.1007/s00464-008-9832-0, PMID 18322735.
33. Chan KW, Lee KH, Wong HY, Tsui SY, Wong YS, Pang KY, Mou JW, Tam YH. Laparoscopic excision of Meckel’s diverticulum in children: what is the current evidence? World J Gastroenterol. 2014 Nov;20(41):15158-62. doi: 10.3748/wjg.v20.i41.15158, PMID 25386065.
34. Mackey WC, Dineen P. A fifty year experience with Meckel’s diverticulum. Surg Gynecol Obstet. 1983;156(1):56-64. PMID 6600203, Google Scholar.
35. Onen A, Ciğdem MK, Oztürk H, Otçu S, Dokucu AI. When to resect and when not to resect an asymptomatic Meckel’s diverticulum: an ongoing challenge. Pediatr Surg Int. 2003;19(1-2):57-61. doi: 10.1007/s00383-002-0850-z, PMID 12721725, Google Scholar.
36. Robijn J, Sebrechts E, Miserez M. Management of incidentally found Meckel’s diverticulum a new approach: resection based on a Risk Score. Acta Chir Belg. 2006;106(4):467-70. doi: 10.1080/00015458.2006.11679933, PMID 17017710, Google Scholar.
37. Ueberrueck T, Meyer L, Koch A, Hinkel M, Kube R, Gastinger I. The significance of Meckel’s diverticulum in appendicitis—a retrospective analysis of 233 cases. World J Surg. 2005;29(4):455-8. doi: 10.1007/s00268-004-7615-x, PMID 15776296, Google Scholar.
38. Cullen JJ, Kelly KA, Moir CR, Hodge DO, Zinsmeister AR, Melton LJ. Surgical management of Meckel’s diverticulum. An epidemiologic, population-based study. Ann Surg. 1994;220(4):564-8; discussion 568. (PMC Free article). doi: 10.1097/00000658-199410000-00014, PMID 7944666, Google Scholar.
39. Passarge E, Stevenson RE. Meckel’s diverticulum. In: Human malformations and related anomalies,2nd, Stevenson RE, Hall JE(Eds). Oxford: Oxford University Press; 2006. p. 1111.
40. Michel ML, Field RJ, Ogden WW. Meckel’s diver ticulum: analysis of 100 cases and report of giant diverticulum and of cases occurring within same immediate family. Ann Surg. 1955;11(819):829.
41. Smith SW, Woodward ER. Peptic ulcer in Meckel’s diverticulum; bleeding and perforation in two male siblings. Ann Surg. 1955;142(6):1021-5. doi: 10.1097/00000658-195512000-00022, PMID 13269063.
42. Abramson DJ. Perforation of Meckel’s diverticulum, peritonitis, and intestinal obstruction in newborn with survival: Meckel’s diverticulum in siblings. J Child. 1960;100:277-81.
43. Patoulias I, Kogia E, Feidantsis T, Michou P, Kalogirou MS, Mitsoulis S, Patoulias DI. Prz Gastroenterol. 2020;15(1):80-1.
2. Sagar J, Kumar V, Shah DK. Meckel’s diverticulum: a systematic review. J R Soc Med. 2006;99(10):501-5. (PMC Free article). doi: 10.1258/jrsm.99.10.501, PMID 17021300, Google Scholar.
3. Hansen CC, Søreide K. Systematic review of epidemiology, presentation, and management of Meckel’s diverticulum in the 21st century [presentation]. Medicine. 2018;97(35):e12154. (PMC Free article). doi: 10.1097/MD.0000000000012154, PMID 30170459, Google Scholar.
4. Matsukuma Y, Matsuo Y, Sakaguchi M, Yamada T, Hirata T, Tanaka N, Morita J, Araki H, Sue K, Kaneko T, et al. A case of siblings with Meckel’s diverticulum diagnosed before operation. Acta Paediatr Jpn. 1994;36(3):291-3. doi: 10.1111/j.1442-200x.1994.tb03183.x, PMID 8091981, Google Scholar.
5. Primrose JM, Henry RB. Symptomatic familial Meckel’s diverticulum: two case reports and literature review. S D. J Med. 1977;30:7-9.
6. Lewenstein HJ, Levenson SS. Familial occurrence of Meckel’s diverticulum. N Engl J Med. 1963;268:311-2. doi: 10.1056/NEJM196302072680611, PMID 13930306.
7. Stone PA, Hofeldt MJ, Lohan JA, Kessel JW, Flaherty SK. A rare case of massive gastrointestinal hemorrhage caused by Meckel’s diverticulum in a 53-year-old man. W V Med J. 2005;101(2):64-6. PMID 16042089, Google Scholar.
8. Yorganci K, Ozdemir A, Hamaloglu E, Sokmener C. Perforation of acute calculous Meckel’s diverticulitis: a rare cause of acute abdomen in elderly. Acta Chir Belg. 2000;100(5):226-7. PMID 11143326, Google Scholar.
9. Cserni G. Gastric pathology in Meckel’s diverticulum. Review of cases resected between 1965 and 1995. Am J Clin Pathol. 1996;106(6):782-5. doi: 10.1093/ajcp/106.6.782, PMID 8980355, Google Scholar.
10. Ihedioha U, Panteleimonitis S, Patel M, Duncan A, Finch GJ. An unusual presentation of Meckel’s diverticulum. J Surg Case Rep. 2012;2012(3):4. doi: 10.1093/jscr/2012.3.4. (PMC Free article). PMID 24960808 [CrossRef]. Google Scholar.
11. Park JJ, Wolff BG, Tollefson MK, Walsh EE, Larson DR. Meckel diverticulum: the Mayo Clinic experience with 1476 patients (1950-2002). Ann Surg. 2005;241(3):529-33. (PMC Free article). doi: 10.1097/01.sla.0000154270.14308.5f, PMID 15729078, Google Scholar.
12. Dumper J, Mackenzie S, Mitchell P, Sutherland F, Quan ML, Mew D. Complications of Meckel’s diverticula in adults. Can J Surg. 2006;49(5):353-7. PMID 17152574.
13. Kusumoto H, Yoshida M, Takahashi I, Anai H, Maehara Y, Am Sugimachi K. Complications and diagnosis of Meckel’s diverticulum in 776 patients. Am J Surg. 1992 Oct;164(4):382-3. doi: 10.1016/s0002-9610(05)80909-2, PMID 1415948.
14. Heinicke JM, Tedaldi R, Muller C. An unusual manifestation of Meckel’s diverticulum: bleeding and perforation—a case report. Swiss Surg. 1997;3(3):97-9. PMID 9200969, Google Scholar.
15. Wong JH, Suhaili DN, Kok KY. Fish bone perforation of Meckel’s diverticulum: a rare event? Asian J Surg. 2005;28(4):295-6. doi: 10.1016/s1015-9584(09)60364-x, PMID 16234083, Google Scholar.
16. Tan YM, Zheng ZX. Recurrent torsion of a giant Meckel’s diverticulum. Dig Dis Sci. 2005;50(7):1285-7. doi: 10.1007/s10620-005-2774-7, PMID 16047474, Google Scholar.
17. Puligandla PS, Becker L, Driman D, Prokopiw I, Taves D, Davies ET. Inverted Meckel’s diverticulum presenting as chronic anemia: case report and literature review. Can J Surg. 2001;44(6):458-9. (PMC Free article). PMID 11764882, Google Scholar.
18. Soltero MJ, Bill AH. The natural history of Meckel’s diverticulum and its relation to incidental removal. A study of 202 cases of diseased Meckel’s diverticulum found in King County, Washington, over a fifteen year period. Am J Surg. 1976;132(2):168-73. doi: 10.1016/0002-9610(76)90043-x, PMID 952346, Google Scholar.
19. Kusumoto H, Yoshida M, Takahashi I, Anai H, Maehara Y, Am Sugimachi K. Complications and diagnosis of Meckel’s diverticulum in 776 patients. Am J Surg. 1992 Oct;164(4):382-3. doi: 10.1016/s0002-9610(05)80909-2, PMID 1415948.
20. Ymaguchi M, Takeuchi S, Awazu S. Meckel’s diverticulum. Investigation of 600 patients in Japanese literature. Am J Surg. 1978;136(2):247-9. doi: 10.1016/0002-9610(78)90238-6, PMID 308325.
21. Lorusso R, Forte A, Urbano V, Soda G, D’Urso A, Bosco MR, Mancini P, Bezzi M. Small bowel stromal tumors in a ”Meckelian” location. About a clinical observation. Ann Ital Chir. 2003;74(6):707-11. PMID 15206814, Google Scholar.
22. Sutter PM, Canepa MG, Kuhrmeier F, Marx A, Martinoli S. Carcinoid tumor in Meckel’s diverticulum: case presentation and review of the literature. Schweiz Med Wochenschr Suppl. 1997;89:20S-4S. PMID 9289835, Google Scholar.
23. Stone PA, Hofeldt MJ, Campbell JE, Vedula G, DeLuca JA, Flaherty SK. Meckel diverticulum: ten-year experience in adults. South Med J. 2004;97(11):1038-41. doi: 10.1097/01.SMJ.0000125222.90696.03, PMID 15586591, Google Scholar.
24. Nayak B, Dash RR, Mallik BN. Perforated Meckel’s diverticulum as a result of gastrointestinal stromal tumor presenting as acute abdomen: A rare case report. Onc Gas Hep Rep. 2015;4(1):26. doi: 10.4103/2348-3113.139636.
25. Parente F, Anderloni A, Zerbi P, Lazzaroni M, Sampietro G, Danelli P, Bianchi Porro G. Intermittent small-bowel obstruction caused by gastric adenocarcinoma in a Meckel’s diverticulum. Gastrointest Endosc. 2005;61(1):180-3. doi: 10.1016/s0016-5107(04)02450-2, PMID 15672086.
26. Hager M, Maier H, Eberwein M, Klingler P, Kolbitsch C, Tiefenthaler W, Mikuz G, Moser PL. Perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor: a case report. J Gastrointest Surg. 2005;9(6):809-11. doi: 10.1016/j.gassur.2004.12.005, PMID 16189886.
27. Payne-James JJ, Law NW, Watkins RM. Carcinoid tumour arising in a Meckel’s diverticulum. Postgrad Med J. 1985;61(721):1009-11. doi: 10.1136/pgmj.61.721.1009, PMID 4070108.
28. Dimitriou I, Evaggelou N, Tavaki E, et al. PMC free articlePerforation of Meckel’s diverticulum by a fish bone presenting as acute appendicitis: a case report. J Med Case Rep. 2013;7:231. doi: 10.1186/1752-1947-7-231, PMID 24088307 [CrossRef]. Google Scholar.
29. Chan KW. Perforation of Meckel’s diverticulum caused by a chicken bone: a case report. J Med Case Rep. 2009;3:48. doi: 10.1186/1752-1947-3-48. (PMC Free article). PMID 19192283 [CrossRef], Google Scholar.
30. Ding Y, Zhou Y, Ji Z, Zhang J, Wang Q. Laparoscopic management of perforated Meckel’s diverticulum in adults. Int J Med Sci. 2012;9(3):243-7. doi: 10.7150/ijms.4170. (PMC Free article). PMID 22577339 [CrossRef], Google Scholar.
31. Shalaby RY, Soliman SM, Fawy M, Samaha A. Laparoscopic management of Meckel’s diverticulum in children. J PediatrSurg. J Pediatr Surg. 2005;40(3):562-7. doi: 10.1016/j.jpedsurg.2004.11.032, PMID 15793736, Google Scholar.
32. Chan KW, Lee KH, Mou JW, Cheung ST, Tam YH. Laparoscopic management of complicated Meckel’s diverticulum in children: a 10-year review. Surg Endosc. 2008 Jun;22(6):1509-12. doi: 10.1007/s00464-008-9832-0, PMID 18322735.
33. Chan KW, Lee KH, Wong HY, Tsui SY, Wong YS, Pang KY, Mou JW, Tam YH. Laparoscopic excision of Meckel’s diverticulum in children: what is the current evidence? World J Gastroenterol. 2014 Nov;20(41):15158-62. doi: 10.3748/wjg.v20.i41.15158, PMID 25386065.
34. Mackey WC, Dineen P. A fifty year experience with Meckel’s diverticulum. Surg Gynecol Obstet. 1983;156(1):56-64. PMID 6600203, Google Scholar.
35. Onen A, Ciğdem MK, Oztürk H, Otçu S, Dokucu AI. When to resect and when not to resect an asymptomatic Meckel’s diverticulum: an ongoing challenge. Pediatr Surg Int. 2003;19(1-2):57-61. doi: 10.1007/s00383-002-0850-z, PMID 12721725, Google Scholar.
36. Robijn J, Sebrechts E, Miserez M. Management of incidentally found Meckel’s diverticulum a new approach: resection based on a Risk Score. Acta Chir Belg. 2006;106(4):467-70. doi: 10.1080/00015458.2006.11679933, PMID 17017710, Google Scholar.
37. Ueberrueck T, Meyer L, Koch A, Hinkel M, Kube R, Gastinger I. The significance of Meckel’s diverticulum in appendicitis—a retrospective analysis of 233 cases. World J Surg. 2005;29(4):455-8. doi: 10.1007/s00268-004-7615-x, PMID 15776296, Google Scholar.
38. Cullen JJ, Kelly KA, Moir CR, Hodge DO, Zinsmeister AR, Melton LJ. Surgical management of Meckel’s diverticulum. An epidemiologic, population-based study. Ann Surg. 1994;220(4):564-8; discussion 568. (PMC Free article). doi: 10.1097/00000658-199410000-00014, PMID 7944666, Google Scholar.
39. Passarge E, Stevenson RE. Meckel’s diverticulum. In: Human malformations and related anomalies,2nd, Stevenson RE, Hall JE(Eds). Oxford: Oxford University Press; 2006. p. 1111.
40. Michel ML, Field RJ, Ogden WW. Meckel’s diver ticulum: analysis of 100 cases and report of giant diverticulum and of cases occurring within same immediate family. Ann Surg. 1955;11(819):829.
41. Smith SW, Woodward ER. Peptic ulcer in Meckel’s diverticulum; bleeding and perforation in two male siblings. Ann Surg. 1955;142(6):1021-5. doi: 10.1097/00000658-195512000-00022, PMID 13269063.
42. Abramson DJ. Perforation of Meckel’s diverticulum, peritonitis, and intestinal obstruction in newborn with survival: Meckel’s diverticulum in siblings. J Child. 1960;100:277-81.
43. Patoulias I, Kogia E, Feidantsis T, Michou P, Kalogirou MS, Mitsoulis S, Patoulias DI. Prz Gastroenterol. 2020;15(1):80-1.
How to Cite
Rahul George, Vijy Paul Thomas, Beauty Sasidharan, & Joicy Els Jojo. (2022). Familial Meckel’s diverticulum - still a mystery. A retrospective caseseries in a tertiary care centre in South India. Surgical Review: International Journal of Surgery, Trauma and Orthopedics, 7(5), 130-136. Retrieved from https://surgical.medresearch.in/index.php/ijoso/article/view/238
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Case Series
Copyright (c) 2022 Author (s). Published by Siddharth Health Research and Social Welfare Society
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