Idiopathic Granulomatous Mastitis – Still an Enigma

  • Vijy Paul Thomas MS, MRCSED, Professor, Department of General Surgery, MOSC Medical College and Hospital, Kolenchery, Ernakulam,Kerala, India
  • Rahul George MS, Assistant Professor, Department of General Surgery, MOSC Medical College and Hospital, Kolenchery, Ernakulam,Kerala, India
  • Lakshmi Malavika Nair MBBS, Junior Resident, Department of General Surgery, MOSC Medical College and Hospital, Kolenchery,Ernakulam, Kerala, India
  • joicy Els Jojo MBBS, Junior Resident, Department of General Surgery, MOSC Medical College and Hospital, Kolenchery, Ernakulam,Kerala, India
Keywords: idiopathic, granulomatous, mastitis

Abstract

Introduction: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease of thebreast, the aetiology of which has, as yet, not been fully established. The disease granulomatousmastitis was first described in the year 1972.

Purpose: To date, there have been numerous reportsregarding the symptoms, clinical examination, imaging findings and treatment options; however noprotocol for evaluation and treatment has been established.

Methods: A systematic search of theliterature was performed using a defined search strategy and articles selected after adequateindependent screening for suitability. The general understanding of the pathophysiology of thedisease as well as the various methods of investigation and treatment employed in the variousstudies were analysed.

Results: The most common modalities used for evaluation were ultrasoundscans and mammograms with some role for MRI scans too. Core biopsy is ideal to obtain a tissuediagnosis. Regarding the treatment, many options have been successfully used of which antibiotics,steroids and surgery have been the most common. Conclusion:

Consensus for an investigation andtreatment protocol will require more studies in future.

Downloads

Download data is not yet available.

References

Kessler E., Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J ClinPathol. 1972;58:642–646.

2 Benson JR, Dumitru D.Idiopathic granulomatous mastitis: presentation, investigation and management.
Future Oncol. 2016 Jun; 12(11):1381-94.

3 Gautier N, Lalonde L, Tran-Thanh D, El Khoury M, David J, Labelle M, Patocskai E, Trop I. Chronic granulomatous mastitis: Imaging, pathology and management. Eur J Radiol. 2013 Apr; 82(4):e165-75.

4 Erhan Y, Veral A, Kara E, Ozdemir N, Kapkac M, Ozdedeli E, Yilmaz R, Koyuncu A, Erhan Y, Ozbal O. A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis.
Breast. 2000 Feb; 9(1):52-6.

5 Kiyak G, Dumlu EG, Kilinc I, Tokaç M, Akbaba S, Gurer A, Ozkardes AB, Kilic M
Management of idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment. BMC Surg. 2014 Sep 4; 14():66.

6 Pandey TS, Mackinnon JC, Bressler L, Millar A, Marcus EE, Ganschow PS. Idiopathic granulomatous mastitis--a prospective study of 49 women and treatment outcomes with steroid therapy. Breast J. 2014 May-Jun; 20(3):258-66.

7Imoto S, Kitaya T, Kodama T, Hasebe T, Mukai K Idiopathic granulomatous mastitis: case report and review of the literature. Jpn J ClinOncol. 1997;1:27–277

8Baslaim M.M., Khayat H.A., Al-Amoudi S.A. Idiopathic granulomatous mastitis: a heterogeneous disease with variable clinical presentation. World J Surg. 2007;31:1677–1681

9Vinay Mathew Thomas, Swetha Ann Alexander, PoorvaBindal, James Vredenburgh. Idiopathic Granulomatous Mastitis – A Mystery Yet to be Unraveled: A Case Series and Review of Literature. Cureus 2020 Feb;12(2): e6895. Published online 2020 Feb5

10Nour AH, Imad U, Rayan R, HazenIA. Idiopathi Granulomatous Mastitis Presenting as a Breast Pseudotumour: Case Reports with Review of Literature. Case Rep Rheumatol.2018; 2018:4264012

11Paviour S., Musaad S., Roberts S., et al. CorynebacteriumSpecies isolated from patients with mastitis. Clinical Infectious Diseases. 2002;35(11):1434–1440

12Rommie Merino-Alado, Jacinto Pineda, Juan Hernandez Rasquin, Maria Eugenia Landaeta, Sofía Mata-Essayag. Granulomatous mastitis due to coinfection with Histoplasma sp. And Paracoccidioides sp.: A case report. Med Mycol Case Rep. 2020 Mar; 27: 52–54. Published online 2020 Jan 16

13Marione Carolina,D. Palumbo Vincenzo, Maffongelli Angela, Damiano Giuseppe et al. Diagnostic techniques and multidisciplinary approach in Idiopathic Granulomatous Mastitis: a revision of literature. Acta Biomed 2019;90(1):11-15

14Rami Y, Shadi H, Nehad MA, Lamees Y and TaglebM. A Proposal of a Clinically Based Classification for Idiopathoc Granulomatous Mastitis. Asian Pac J Cancer Prev. 2019;20(3):929-934

15Irmak Durur-Subasi. Diagnostic and Interventional Radiology in Idiopathic Granulomatous Mastitis. Eurasian J Med. 2019 Oct;51(3):293-297

16Lai EC, Chan WC, MA TK, Tang AP, Poon CS, Leong HT.The role of conservative treatment in Idiopathic Granulomatous Mastitis. Breast J.2005;11:454-456

17Scoglietti V, Woodridge R, Leitch M et al. Development and initiation of a clinical protocol for the treatment of idiopathic granulomatous mastitis. Journal of Rare Disorders. 2014;2(1):1-6

18Pandey TS, Mackinnon JC, Bressler L, Millar A, Marcus EC, Ganschow PS. Bresst J. 2014;20:258-266

19Benson JR, Dumitru D. Idiopathic Granulomatous Mastitis: presentation, investigation and management. Future Oncol.2016;12:1381-1394

20Demetrios M, Christa D, SpyndonD et al. Is Idiopathi Granulomatous Mastitis a surgical disease? The jury is still out. Ann Transl Med 2017 Aug;5(15):309

21Kin J, Tymm KE, Buckingham JM. Methotrexate in the management of granulomatous mastitis. ANZ J Surg.2003;73:247-249Guler SA, Baran MA et al. Scoring Idiopathic Granulomatous Mastitis: An effective scoring system for predicting recurrence. Eur J Breast Health.2018 April1;14(2)112-116

22Oran ES, Gurdal SO, Yankol Y. Management of idiopathic granulomatous mastitis: a heterogenous disease with variable clinical presentation. World J Surg. 2007;31:1677-1681

23Fei Zhou, Li-Xang Yu, Zhong-Bing MA, Zhi-Gang Yu. Granulomatous lobular mastitis.Chronic Dis Transl Med.2016 Mar;2(1):17-21

24Hasan K, IlkerO, Serife S et al. Can Steroids plus Surgery Become a First Line Treatment of Idiopathic Granulomatous Mastitis? Breast Care (Basel) 2014 Oct;9(5):338-342

25Masao Y, Masahiro W, Sayiri I et al. Management of Granulomatous Mastitis: A Series of 13 Patients who were evelauated for treatment without Corticosteroids. IntSurg 2015 May;100(5):774-782

26Ali K, Umut K, Ismail D, Yusuf AK et al. Combined Long-Term Steroid and Immunosuppressive Treatment Regimen in Granulomatous Mastitis. Breast Care (Basel) 2012 Aug;7(4):297-301
How to Cite
Vijy Paul Thomas, Rahul George, Lakshmi Malavika Nair, & joicy Els Jojo. (2022). Idiopathic Granulomatous Mastitis – Still an Enigma. Surgical Review: International Journal of Surgery, Trauma and Orthopedics, 7(5), 123-129. Retrieved from https://surgical.medresearch.in/index.php/ijoso/article/view/219
Section
Review Article