A Comparative study of efficacy of Thiocolchicoside with Diclofenac vs Eperisone with Diclofenac in patients with back pain
Keywords:
Low back pain, Thiocolchicoside, Eperisone
Abstract
Background: A number of drugs are available for the treatment of Low back pain (LBP) as per the available literature. This study was undertaken to compare the efficacy of Thiocolchicoside– diclofenac and Eperisone – diclofenac in patients with low back pain.
Materials and Methods: A prospective, open labeled, randomized, comparative clinical study was conducted in order to establish the efficacy of Thiocolchicoside – diclofenac and Eperisone – diclofenac in patients with back pain. Thirty patients of either sex with back pain were randomly allocated to two groups to receive either Thiocolchicoside (4 mg)+Diclofenac (50mg) twice a day (Group A) or Eperisone (150 mg) Sustained Release+Diclofenac (100mg) preparation once a day (Group B).
Results: The finger to floor distance was improved significantly after treatment with both the drugs for 7 days. There was a statistically significant difference in improvement of finger to floor distance of both the drugs and was marked in Group B. About 80% of the patients were normal after 7 days of treatment in Group B. The VAS scores and Global assessment scale had also shown the lower scores for group B compared to group A.
Conclusion: The Eperisone with diclofenac was found to be more effective in terms of Finger floor distance and improvement in Lasegue’s sign, VAS score and global assessment scale than Thiocolchicoside with Diclofenac.
Downloads
Download data is not yet available.
References
1. Doherty M, Laryon P, Ralston SH. Presenting problems in musculoskeletal diseases; Back & neck pain. In: Boon NA, Colledge NR, Walker BR. Davidson’s The Principle & Practice of Medicine Churchill Livingstone, Elsevier London, Edition 20;2006:1083-84.
2. Panchapakesa RC. Low back pain. In: Shah SN, Paul AN,; API Text book of Medicine .The Association of Physician of India, Mumbai Edition 7;2007:1148-1151.
3. Moore RA, Straube S, Derry S, McQuay HJ. Chronic low back pain analgesic studies--a methodological minefield.Pain. 2010 Jun;149(3):431-4. doi: 10.1016/j.pain.2010.02.032. Epub 2010 Mar 20. [PubMed]
4. Chandanwale AS, Chopra A, Goregaonkar A, Medhi B, Shah V, Gaikwad S, Langade DG, Maroli S, Mehta SC, Naikwadi A, Pawar DR. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebo-controlled trial. J Postgrad Med. 2011 Oct-Dec;57(4):278-85. doi: 10.4103/0022-3859.90076.
5. Chandanwale AS, Chopra A, Goregaonkar A et al. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebo-controlled trial. J Postgrad Med. 2011 Oct-Dec;57(4):278-85. doi: 10.4103/0022-3859.90076.
6. Burton AK, Balagué F, Cardon G, Eriksen HR, Henrotin Y, Lahad A, Leclerc A, Müller G, van der Beek AJ; COST B13 Working Group on Guidelines for Prevention in Low Back Pain. Chapter 2. European guidelines for prevention in low back pain : November 2004. Eur Spine J. 2006 Mar;15Suppl 2:S136-68.
7. Ketenci A, Ozcan E, Karamursel S. Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.Int J ClinPract. 2005 Jul;59(7):764-70. [PubMed]
8. Maaz SH, Khandelwal PN, Baig SM, Doifode SM, Ghotkar UM, Evaluation of the efficacy and tolerability of eprisone and thocolchicoside in treatment of low back pain associated with muscle spasm: A open label, prospective, randomized control trial, IJBP: 2016: November – December: 6: 2669.
9. Gold MS. Na(+) channelblockers for the treatment of pain: context is everything, almost. Exp Neurol. 2008 Mar;210(1):1-6. doi: 10.1016/j.expneurol.2007.12.001. Epub 2007 Dec 8. [PubMed]
10. Cabitza P, Randelli P. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. European Review for Medical and Pharmacological Sciences. 2008;12:229- 35.
11. Hawker GA, Mian S, Kendzerska T, French M. Measures of adultpain: Visual Analog Scale for Pain (VASPain), Numeric RatingScale for Pain (NRSPain), McGill Pain Questionnaire (MPQ), Short-FormMcGill Pain Questionnaire (SF-MPQ), Chronic PainGradeScale (CPGS), Short Form-36BodilyPainScale (SF-36BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). ArthritisCare Res (Hoboken).2011 Nov;63Suppl 11:S240-52. doi: 10.1002/acr.20543.
12. Nikiphorou E, Radner H, Chatzidionysiou K, Desthieux C, Zabalan C, van Eijk-Hustings Y, Dixon WG, Hyrich KL, Askling J, Gossec L. Patientglobalassessment in measuringdiseaseactivity in rheumatoid arthritis: a review of the literature. Arthritis ResTher.2016 Oct 28;18(1):251. [PubMed]
13. Magnusson SP, Simonsen EB, Aagaard P, Boesen J, Johannsen F, Kjaer M. Determinants of musculoskeletalflexibility: viscoelasticproperties, cross-sectionalarea, EMG and stretchtolerance. Scand J Med Sci Sports. 1997 Aug;7(4):195-202. [PubMed]
14. Chou R. Pharmacological management of low back pain.Drugs. 2010 Mar 5;70(4):387-402. doi: 10.2165/11318690-000000000-00000. [PubMed]
15. Umarkar AR, Bavaskar SR, Yewale PN. Thiocolchicoside as muscle relaxant: a review. International Journal of Pharmacy and Biological Sciences 2011;1(3):364-71.
16. Tanaka K, Kaneko T, Yamatsu K. [Effects of 4'ethyl-2-methyl-3-piperidinopropiophenone on experimental rigidity and spinal cord activities (author's transl)].Nihon YakurigakuZasshi. 1981 May;77(5):511-20.
17. Maaz SH, Khandelwal PN, Baig SM, Doifode SM, Ghotkar UM. Evaluation of efficacy and tolerability of eperisone and thiocolchicoside in treatment of low back pain associated with muscle spasm: An open label, prospective, randomized controlled trial. Int J Basic ClinPharmacol 2016;5:2669-74.
18. Rao R, Panghate A, Chandanwale A, Sardar I, Ghosh M, Roy M, Banerjee B, Goswami A, Kotwal PP. Clinicalcomparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinalmuscle spasticity. Asian Spine J. 2012 Jun;6(2):115-22. doi: 10.4184/asj.2012.6.2.115. Epub 2012 May 31. [PubMed]
19. Soonawalla DF, Joshi N. Efficacy of thiocolchicoside in Indian patients suffering from low back painassociated with muscle spasm. J Indian Med Assoc. 2008 May;106(5):331-5. [PubMed]
20. Frandisco CR, Ramon VP, Enrique RB, Francisco FB. Effect of two different doses of Eperisone in treatment of acute low back pain.The J of Applied Research. 2009;9(1):23-9.
2. Panchapakesa RC. Low back pain. In: Shah SN, Paul AN,; API Text book of Medicine .The Association of Physician of India, Mumbai Edition 7;2007:1148-1151.
3. Moore RA, Straube S, Derry S, McQuay HJ. Chronic low back pain analgesic studies--a methodological minefield.Pain. 2010 Jun;149(3):431-4. doi: 10.1016/j.pain.2010.02.032. Epub 2010 Mar 20. [PubMed]
4. Chandanwale AS, Chopra A, Goregaonkar A, Medhi B, Shah V, Gaikwad S, Langade DG, Maroli S, Mehta SC, Naikwadi A, Pawar DR. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebo-controlled trial. J Postgrad Med. 2011 Oct-Dec;57(4):278-85. doi: 10.4103/0022-3859.90076.
5. Chandanwale AS, Chopra A, Goregaonkar A et al. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebo-controlled trial. J Postgrad Med. 2011 Oct-Dec;57(4):278-85. doi: 10.4103/0022-3859.90076.
6. Burton AK, Balagué F, Cardon G, Eriksen HR, Henrotin Y, Lahad A, Leclerc A, Müller G, van der Beek AJ; COST B13 Working Group on Guidelines for Prevention in Low Back Pain. Chapter 2. European guidelines for prevention in low back pain : November 2004. Eur Spine J. 2006 Mar;15Suppl 2:S136-68.
7. Ketenci A, Ozcan E, Karamursel S. Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.Int J ClinPract. 2005 Jul;59(7):764-70. [PubMed]
8. Maaz SH, Khandelwal PN, Baig SM, Doifode SM, Ghotkar UM, Evaluation of the efficacy and tolerability of eprisone and thocolchicoside in treatment of low back pain associated with muscle spasm: A open label, prospective, randomized control trial, IJBP: 2016: November – December: 6: 2669.
9. Gold MS. Na(+) channelblockers for the treatment of pain: context is everything, almost. Exp Neurol. 2008 Mar;210(1):1-6. doi: 10.1016/j.expneurol.2007.12.001. Epub 2007 Dec 8. [PubMed]
10. Cabitza P, Randelli P. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. European Review for Medical and Pharmacological Sciences. 2008;12:229- 35.
11. Hawker GA, Mian S, Kendzerska T, French M. Measures of adultpain: Visual Analog Scale for Pain (VASPain), Numeric RatingScale for Pain (NRSPain), McGill Pain Questionnaire (MPQ), Short-FormMcGill Pain Questionnaire (SF-MPQ), Chronic PainGradeScale (CPGS), Short Form-36BodilyPainScale (SF-36BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). ArthritisCare Res (Hoboken).2011 Nov;63Suppl 11:S240-52. doi: 10.1002/acr.20543.
12. Nikiphorou E, Radner H, Chatzidionysiou K, Desthieux C, Zabalan C, van Eijk-Hustings Y, Dixon WG, Hyrich KL, Askling J, Gossec L. Patientglobalassessment in measuringdiseaseactivity in rheumatoid arthritis: a review of the literature. Arthritis ResTher.2016 Oct 28;18(1):251. [PubMed]
13. Magnusson SP, Simonsen EB, Aagaard P, Boesen J, Johannsen F, Kjaer M. Determinants of musculoskeletalflexibility: viscoelasticproperties, cross-sectionalarea, EMG and stretchtolerance. Scand J Med Sci Sports. 1997 Aug;7(4):195-202. [PubMed]
14. Chou R. Pharmacological management of low back pain.Drugs. 2010 Mar 5;70(4):387-402. doi: 10.2165/11318690-000000000-00000. [PubMed]
15. Umarkar AR, Bavaskar SR, Yewale PN. Thiocolchicoside as muscle relaxant: a review. International Journal of Pharmacy and Biological Sciences 2011;1(3):364-71.
16. Tanaka K, Kaneko T, Yamatsu K. [Effects of 4'ethyl-2-methyl-3-piperidinopropiophenone on experimental rigidity and spinal cord activities (author's transl)].Nihon YakurigakuZasshi. 1981 May;77(5):511-20.
17. Maaz SH, Khandelwal PN, Baig SM, Doifode SM, Ghotkar UM. Evaluation of efficacy and tolerability of eperisone and thiocolchicoside in treatment of low back pain associated with muscle spasm: An open label, prospective, randomized controlled trial. Int J Basic ClinPharmacol 2016;5:2669-74.
18. Rao R, Panghate A, Chandanwale A, Sardar I, Ghosh M, Roy M, Banerjee B, Goswami A, Kotwal PP. Clinicalcomparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinalmuscle spasticity. Asian Spine J. 2012 Jun;6(2):115-22. doi: 10.4184/asj.2012.6.2.115. Epub 2012 May 31. [PubMed]
19. Soonawalla DF, Joshi N. Efficacy of thiocolchicoside in Indian patients suffering from low back painassociated with muscle spasm. J Indian Med Assoc. 2008 May;106(5):331-5. [PubMed]
20. Frandisco CR, Ramon VP, Enrique RB, Francisco FB. Effect of two different doses of Eperisone in treatment of acute low back pain.The J of Applied Research. 2009;9(1):23-9.
CITATION
DOI: 10.17511/ijoso.2017.i01.01
Published: 2017-12-31
How to Cite
S, A., Raju G, N., B, D., & Gowda M R, N. (2017). A Comparative study of efficacy of Thiocolchicoside with Diclofenac vs Eperisone with Diclofenac in patients with back pain. Surgical Review: International Journal of Surgery, Trauma and Orthopedics, 3(1), 1-5. https://doi.org/10.17511/ijoso.2017.i01.01
Section
Original Article
OAI - Open Archives Initiative
Therapoid
